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Sammlung diverse Themen

7 Beiträge ▪ Schlüsselwörter: Gesundheit, Medizin, Ernährung ▪ Abonnieren: Feed E-Mail
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Sammlung diverse Themen

01.11.2024 um 15:09
Unsortierte Materialsammlung mit Videos und Links zu meinen Blog-Themen.
Zum Teil stammt das Material aus meinen Forumsbeiträgen, zum Teil ist es nur hier zu finden.
Dies ist nur ein Archiv, die Diskussionen zu den Themen sollen in geeigneten Threads im Forum stattfinden.


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01.11.2024 um 15:13
Als Notiz: Sehr interessant, aktuellste Forschung läuft auf vielen Kanälen im Bereich Stammzellen und Exosome.
Kann ganz neue klinische Perspektiven eröffnen.

Ein Review als Überblick:
Clinical applications of stem cell-derived exosomes

Fei Tan, Xuran Li, Zhao Wang, Jiaojiao Li, Khawar Shahzad & Jialin Zheng
Quelle: https://www.nature.com/articles/s41392-023-01704-0
After going through production and purification with or without modification, stem cell-derived exosomes have demonstrated tremendous potential in treating numerous diseases encountered during surgical practice. These are exemplified by disorders in orthopedic surgery (e.g., fracture, osteoarthritis, and spinal cord injury); neurosurgery (e.g., ischemic stroke, traumatic brain injury, and Alzheimer’s disease); plastic surgery (e.g., wound healing); general surgery (e.g., acute liver injury); cardiothoracic surgery (e.g., myocardial infarction); urology (e.g., chronic kidney disease); head and neck surgery (e.g., sensorineural hearing loss); ophthalmology (e.g., acquired optic neuropathies), and gynecology (e.g., primary ovarian insufficiency). Mechanistically, the diverse therapeutic effects of stem cell-derived exosomes are achieved through disease-specific cellular and tissue responses (e.g., tissue regeneration, anti-inflammation, anti-cell death, immunomodulation, and anti-oxidative stress) and tissue-specific molecular signaling pathways (e.g., Wnt/β-catenin, PTEN/PI3K/Akt/HIF-1α, MAPK, and JAK/STAT pathways). Collectively, stem cell-derived exosome therapy has been proven to be a potent and versatile surrogate to stem cell therapy in the surgical arena.



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17.11.2024 um 15:10
Notiz zum Thema Korruption in Gesundheit/Ernährung:
Artikel aus dem Guardian im Kontext einer Studie.

https://www.theguardian.com/science/2022/dec/09/academy-nutrition-financial-ties-processed-food-companies-contributions?s=

Billig-Übersetzung von Google, unredigiert:

Enthüllt: Gruppe, die US-Ernährung gestaltet, erhält Millionen von der großen Lebensmittelindustrie

Dokumente zeigen, dass die Academy of Nutrition and Dietetics bereits mit einer Reihe von Lebensmittelgiganten zusammengearbeitet hat

Kürzlich veröffentlichte Dokumente zeigen, dass eine einflussreiche Gruppe, die die US-Lebensmittelpolitik mitgestaltet und Verbraucher zu Nahrungsmitteln lenkt, finanzielle Verbindungen zu den weltweit größten Herstellern verarbeiteter Nahrungsmittel hat und von ehemaligen Mitarbeitern der Branche kontrolliert wird, die für Unternehmen wie Monsanto gearbeitet haben.

Die Dokumente enthüllen, dass die Academy of Nutrition and Dietetics eine Reihe von Quid-pro-quo-Geschäften mit einer Reihe von Nahrungsmittelgiganten getätigt hat, Anteile an Unternehmen für hochverarbeitete Nahrungsmittel besitzt und Millionenspenden von Herstellern von Limonade, Süßigkeiten und verarbeiteten Nahrungsmitteln erhalten hat, die mit Diabetes, Herzkrankheiten, Fettleibigkeit und anderen Gesundheitsproblemen in Verbindung gebracht werden.

Die Ergebnisse sind Teil einer kürzlich veröffentlichten, von Experten überprüften Studie, in der eine Fülle von Finanzdokumenten und internen Mitteilungen untersucht wurde, die durch eine Anfrage nach dem Freedom of Information Act (Foia) erhalten wurden.

„Sie ist unglaublich einflussreich. Wenn die Academy also korrupt ist, dann wird auch die Ernährungspolitik in den USA korrupt sein“, sagte Gary Ruskin, Geschäftsführer von US Right to Know und Mitautor der Studie. Die gemeinnützige Investigativorganisation hat die Studie mit Forschern von gemeinnützigen Organisationen und Universitäten in den USA und Großbritannien entwickelt.

Sie ist unglaublich einflussreich. Wenn also die Akademie korrupt ist, dann wird auch die Ernährungspolitik in den USA korrupt sein.
Gary Ruskin


„Wenn wir jemals die Probleme von Fettleibigkeit und Diabetes in den USA und anderswo lösen wollen, dann müssen wir die Korruption in unseren Gesundheitseinrichtungen bekämpfen“, fügte Ruskin hinzu.

Die Akademie bezeichnet sich selbst als unabhängige Stimme und „vertrauenswürdige Bildungsressource für Verbraucher“. Sie betreibt Lobbyarbeit im Kongress und vertritt und informiert über 110.000 US-Ernährungsberater, die Menschen bei der Entscheidung über ihre Ernährung helfen.

Obwohl die Akademie schon lange wegen ihrer Verbindungen zu großen Lebensmittelkonzernen kritisiert wird, enthüllt die Studie zum ersten Mal die Tiefe ihrer finanziellen Verbindungen.

Die Akademie nahm von 2011 bis 2017 mindestens 15 Millionen Dollar von Unternehmens- und Organisationsspendern an, und über 4,5 Millionen Dollar an zusätzlichen Mitteln gingen an die Stiftung der Akademie. Zu den höchsten Beiträgen gehörten Unternehmen wie Nestlé, PepsiCo, Hershey, Kellogg’s, General Mills, Conagra, der National Dairy Council und der Babynahrungshersteller Abbott Nutrition.

Die Akademie und ihre Stiftung erhielten auch Mittel aus der Lebensmittelindustrie über Sponsoring, was im Grunde eine Gegenleistung ist. In einer E-Mail aus dem Jahr 2015 definierte ein Mitarbeiter der Akademie ein Sponsoring wie folgt: „Wenn ein Unternehmen der Akademie/Stiftung eine Gebühr zahlt und im Gegenzug von der Akademie/Stiftung festgelegte bestimmte Rechte und Vorteile erhält.“

Aus der E-Mail geht hervor, dass die Akademie 2015 einen Sponsoringvertrag mit Abbott unterhielt und darüber diskutierte, wie die Akademie den Einfluss ihrer Ernährungsberater in Kinderarztpraxen nutzen könnte, um Pediasure, eines der Säuglingsnahrungsprodukte des Pharmariesen, zu fördern. Abbott hatte zu diesem Zeitpunkt einen zweijährigen Sponsoringvertrag über 300.000 US-Dollar abgeschlossen.

Die Akademie besaß zum Zeitpunkt des Vertrags und des Plans auch Abbott-Aktien, wie Aufzeichnungen zeigen. Sie besaß auch Aktien von Unternehmen, mit denen sie einen Sponsoringvertrag hatte, PepsiCo, sowie von Geldgebern wie Nestlé.

„Das ist erstaunlich“, sagte Ruskin. „Das gehört in die Hall of Fame der Interessenkonflikte – es ist jenseits aller Vorstellungen.“

Die damalige Leitung der Akademie schien sich der Optik bewusst zu sein.

„Ich persönlich mag Pepsico und habe keine Probleme damit, dass wir es besitzen, aber ich frage mich, ob jemand etwas dazu sagen wird“, schrieb die damalige Schatzmeisterin der Akademie, Donna Martin, in einer E-Mail von 2014. „Hoffentlich sind sie zufrieden, wie es sich gehört! Ich persönlich wäre zufrieden, wenn wir Coca-Cola-Aktien hätten!!“

Die E-Mail von 2015 beschrieb auch eine Verlängerung eines Sponsoringvertrags mit dem National Dairy Council. Im Rahmen der vorgeschlagenen Verlängerung würde der National Dairy Council 1,2 Millionen Dollar für ein Paket zahlen, das „sowohl die Akademie als auch die Stiftung bei der Fortsetzung der gemeinsamen Arbeit rund um Lebensmittel, Ernährung und Landwirtschaft“ unterstützen würde. Weitere in der E-Mail aufgeführte Sponsoren sind die Industriegruppe von Coca-Cola und Conagra, dem Marken wie Reddi-Wip, Slim Jim und Banquet gehören.

Wie aus der E-Mail hervorgeht, war die Academy zum Zeitpunkt der E-Mail von 2015 auch mit Subway im Gespräch, um die „gesünderen Produkte“ der Fast-Food-Kette „zu unterstützen“. Außerdem diskutierte sie über eine Partnerschaft mit dem Schokoriegelhersteller Mars.

2015 sorgte eine Partnerschaft zwischen der Academy und Kraft für Kontroversen, als die Academy dem Unternehmen erlaubte, sein „Kid’s Eat Healthy“-Siegel auf die Verpackungen von Kraft Singles zu drucken, was darauf hindeutete, dass eine unabhängige Quelle den Nährwert des Produkts bestätigt hatte.

Kritiker wiesen jedoch schnell darauf hin, dass das Produkt einen schlechten Nährwert habe; es werde von der Bundesregierung nicht als Käse, sondern als „pasteurisiertes Käseerzeugnis“ eingestuft; und es enthalte Farbstoffe und andere Chemikalien. Angesichts der Gegenreaktionen zog die Academy ihr Siegel zurück.

Etwa 4,5 Millionen Dollar an Unternehmensgeldern von Unternehmen wie General Mills flossen in eine Initiative namens „Champions Program“, die Hunderten von Nichtregierungsorganisationen Gelder zur Verfügung stellte, um Projekte zu unterstützen, „die gesunde Ernährung und einen aktiven Lebensstil für Kinder und ihre Familien fördern“.

Die Academy antwortete nicht auf konkrete Fragen des Guardian, verwies aber auf eine Antwort auf die Studie auf ihrer Website. Sie bestritt Fehlverhalten, sagte, die Studie enthalte sachliche Fehler und sagte, die Studie nehme ihre Finanzdaten aus dem Kontext. Sie sagte, es gebe „strenge“ Richtlinien, um den Einfluss von Unternehmen auf ihre Programmgestaltung zu verhindern.

Die Akademie fügte hinzu, dass die Unternehmensfinanzierung nur einen kleinen Teil der Einnahmen ausmacht und ein unabhängiges Unternehmen ihr Aktienportfolio verwaltet.

„Durch ihre Annahmen, Auslassungen und Verzerrungen haben die Autoren des Berichts der Akademie, unseren Mitgliedern und dem gesamten Ernährungs- und Diätetikberuf einen schweren Bärendienst erwiesen“, heißt es in der Erklärung.

Die Dokumente tauchten nur auf, weil Martin, eine ehemalige Präsidentin der Akademie, die für einen öffentlichen Schulbezirk in Georgia arbeitet, ihre Schul-E-Mail für Angelegenheiten der Akademie nutzte, was bedeutete, dass die Kommunikation dem FOIA-Gesetz unterlag.

Die Studie hebt auch die Drehtür zwischen der Akademie und der Industrie hervor. Zu ihren Mitarbeitern und Vorstandsmitgliedern zählen aktuelle und ehemalige PR-Mitarbeiter von Unternehmen, die große Lebensmittelunternehmen vertreten, sowie Berater oder Mitarbeiter großer Lebensmittelunternehmen wie Monsanto, Sodexo, der Sugar Association, Bayer und des International Food Information Council sowie von Branchen-Tarnorganisationen.

Die Akademie, die früher American Dietetic Association hieß, scheint „seit ich die Akademie kenne“ unter der Kontrolle großer Lebensmittelinteressen zu stehen, sagte Marion Nestle, eine Ernährungswissenschaftlerin und Verfechterin der öffentlichen Gesundheit, die in ihrem Buch „Food Politics“ aus dem Jahr 2002 über die Verbindungen schrieb. Sie sagte, die finanziellen Verbindungen werfen „grundlegende Fragen zur Glaubwürdigkeit“ auf.

„Wie kann die Akademie der Öffentlichkeit beispielsweise raten, hochverarbeitete Lebensmittel zu meiden, wenn sie von den Herstellern dieser Lebensmittel finanziert wird?“, fragte sie. „Die Frage des Vertrauens ist für die Ernährungsberatung von entscheidender Bedeutung. Die Akademie scheint die Lebensmittelindustrie zu vertreten und nicht das öffentliche Interesse.“



Hier die erwähnte Studie:
The corporate capture of the nutrition profession in the USA: the case of the Academy of Nutrition and Dietetics
Published online by Cambridge University Press: 24 October 2022

https://www.cambridge.org/core/journals/public-health-nutrition/article/corporate-capture-of-the-nutrition-profession-in-the-usa-the-case-of-the-academy-of-nutrition-and-dietetics/9FCF66087DFD5661DF1AF2AD54DA0DF9#

Die Zusammenfassung, wieder in der Google-Übersetzung und unredigiert:

Zusammenfassung

Ziel:
Die Beteiligung von Unternehmen, die gesundheitsschädliche Rohstoffe herstellen, an der Gesundheitspolitik und -forschung wurde als wichtiger kommerzieller Faktor identifiziert, der zum Anstieg nicht übertragbarer Krankheiten beiträgt. In den USA sind Berufsverbände im Gesundheitswesen dem Einfluss von Unternehmen ausgesetzt. Diese Studie untersucht die Interaktionen zwischen Unternehmen und der Academy of Nutrition and Dietetics (AND) und ihre Auswirkungen auf den Beruf in den USA und weltweit.

Design:
Wir haben eine induktive Analyse von Dokumenten (2014–2020) durchgeführt, die wir durch Informationsfreiheitsanfragen erhalten haben, um die Geschäfte wichtiger AND-Akteure mit Lebensmittel-, Pharma- und Agrarunternehmen zu bewerten. Wir haben diese Informationen auch mit öffentlich verfügbaren Daten trianguliert.

Ort:
USA.

Teilnehmer:
Nicht zutreffend.

Ergebnisse:
Die AND, AND Foundation (ANDF) und ihre wichtigsten Führungskräfte interagieren laufend mit Unternehmen. Dazu gehören Führungskräfte von AND, die Schlüsselpositionen in multinationalen Lebensmittel-, Pharma- oder Agrarunternehmen innehaben, und AND, die finanzielle Zuwendungen von Unternehmen annehmen. Wir fanden heraus, dass die AND Gelder in Unternehmen wie Nestlé, PepsiCo und Pharmaunternehmen investiert hat, interne Richtlinien diskutiert hat, um den Bedürfnissen der Industrie gerecht zu werden, und öffentliche Positionen innehatte, die Unternehmen begünstigten.

Schlussfolgerung:
Die Dokumente enthüllen eine symbiotische Beziehung zwischen der AND, ihrer Stiftung und Unternehmen. Unternehmen unterstützen die AND und die ANDF mit finanziellen Beiträgen. Die AND tritt in einigen politischen Foren als industriefreundliche Stimme auf und vertritt öffentliche Positionen, die mit der Mission der AND, die Gesundheit weltweit zu verbessern, kollidieren.



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08.12.2024 um 14:09
Ganz frisch, veröffentlicht am 4. Dezember 2024:
Eine Veröffentlichung der Radiological Society of North America (RSNA):
Eating High-Processed Foods Impacts Muscle Quality

- The more ultra-processed foods people consumed, the more intramuscular fat they had in their thigh muscles, regardless of caloric intake or physical activity.

- Consuming ultra-processed foods, such as cereals, frozen meals, soft drinks and packaged snacks, may also raise knee osteoarthritis risk.

The researchers found that the more ultra-processed foods people consumed, the more intramuscular fat they had in their thigh muscles, regardless of energy (caloric) intake.

“In an adult population at risk for but without knee or hip osteoarthritis, consuming ultra-processed foods is linked to increased fat within the thigh muscles,” Dr. Akkaya said. “These findings held true regardless of dietary energy content, BMI, sociodemographic factors or physical activity levels.”
Quelle: https://press.rsna.org/timssnet/media/pressreleases/14_pr_target.cfm?ID=2536

Ein deutscher Artikel, der die Sache aufgreift:
https://www.fitbook.de/ernaehrung/hochverarbeitete-lebensmittel-oberschenkelmuskel

Die Studie hat ihre Schwächen (Querschnitt-Studie), aber die radiologischen, bildgebenden Befunde sprechen eine klare Sprache.
Es ist zudem ein weiterer Sargnagel für die Kalorien-Hypothese (CICO; calories in/calories out). Ferner ist die Aussage deutlich, dass zuvorderst die Art der Ernährung die Körperzusammensetzung bestimmt.

Falsche Ernährung lagert intramuskuläres Fett ein und viszerales Fett, das stark zur Inflammation neigt.
Hier ein Video des Viszeral-Fett Experten Dr. Sean O’Mara, der das Ganze aus seiner Perspektive einordnet:
Youtube: Deadly Muscle  Fat directly related to process food consumption not exercise or quantity of calories
Deadly Muscle Fat directly related to process food consumption not exercise or quantity of calories
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Noch Video-Notizen von Dr. Sean:
Youtube: When Distance Running Can be Unhealthy!!!  #healthyaging #health #motivation #prostate #dadbod
When Distance Running Can be Unhealthy!!! #healthyaging #health #motivation #prostate #dadbod
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Fetteinlagerungen ums Herz bei dünnem Marathonläufer - viszerales Fett ist von außen nicht erkennbar. MRI Scans lügen nicht.
- Er propagiert Sprint-Training bzw. maximale Intensitäten.
- Das viszerale Fett fördert Sarkopenie

Hier etwas über "Skinny fat" bzw. "Thin outside, fat inside" TOFI
Das ist nur auf dieses Scans erkennbar.

Youtube: New VEGAN Client from India: ^^^Visceral Fat, TOFI, Why Vegans & Everyone should be scanned by MRI.
New VEGAN Client from India: ^^^Visceral Fat, TOFI, Why Vegans & Everyone should be scanned by MRI.
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Sammlung diverse Themen

10.12.2024 um 15:35
Bart Kay mit der Entkräftigung der typischen Argumente gegen Fleischverzehr/Carvore. Rigoros nach streng wissenschaftlichen Kriterien werden vom Physiologen Mythen auf allgemeinverständlichem Niveau widerlegt. Mit einigen Späßchen drin. Das Meiste sind die bekannten Argumente, ein paar Punkte wurden sonst nicht angesprochen. Daher diese Video-Notiz.

01:00 Fiber (Ballaststoffe)
07:00 Vitamin C
10:57 Cholesterin und gesättigte Fette cause heart disease (mit ab 17:54 Salz und Bluthochdruck und Insulinspiegel / ab 19:24 zum Thema Fleisch: Neu5Gc und TMAO)
22:03 Cholesterin
24:15 Nierenprobleme
28:42 "Carnivore ist nicht the proper diet für jedermann"
31:55 Angst vor high fat / warum macht Fett nicht fett
36:45 Warum machen Carbs hungrig/warum sättigt uns Fett (Insulin etc.)
39:22 Braucht unser Gehirn/unser Organismus Glukose? (41:03 Sportler und Carbs bzw. fat adapted)
43:30 KH unsere bevorzugte Energiequelle?

Youtube: Nutrition LIES - Corrected (with Max German)
Nutrition LIES - Corrected (with Max German)
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Etwas Lobhudelei dabei am Anfang vom Gastgeber. Machstenix :shrug:


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21.01.2025 um 12:13
Notiz zum Thema der falschen Reports zur Energieaufnahme und-Verbrauch in epidemologischen Studien:
Ganz neue Arbeit hier, die die Ungenauigkeiten analysiert. Später mal genau ansehen.
Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake

Abstract
Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years. The resultant regression equation predicts expected TEE from easily acquired variables, such as body weight, age and sex, with 95% predictive limits that can be used to screen for misreporting by participants in dietary studies. We applied the equation to two large datasets (National Diet and Nutrition Survey and National Health and Nutrition Examination Survey) and found that the level of misreporting was >50%. The macronutrient composition from dietary reports in these studies was systematically biased as the level of misreporting increased, leading to potentially spurious associations between diet components and body mass index.
Quelle: https://www.nature.com/articles/s43016-024-01089-5
Die Ernährungsepidemiologie zielt darauf ab, einen Zusammenhang zwischen ernährungsbedingten Belastungen und chronischen Krankheiten herzustellen, aber die Instrumente zur Bewertung der Nahrungsaufnahme sind ungenau. Eine Möglichkeit, unzuverlässige Daten und die Fehlerquellen zu ermitteln, ist der Vergleich der geschätzten Aufnahme mit dem Gesamtenergieverbrauch (TEE). In dieser Studie haben wir die International Atomic Energy Agency Doubly Labeled Water Database verwendet, um eine Vorhersagegleichung für den TEE auf der Grundlage von 6.497 TEE-Messungen bei Personen im Alter von 4 bis 96 Jahren zu erstellen. Die daraus resultierende Regressionsgleichung prognostiziert den erwarteten TEE aus leicht zu erfassenden Variablen wie Körpergewicht, Alter und Geschlecht mit 95%igen Vorhersagegrenzen, die zum Screening auf falsche Angaben der Teilnehmer an Ernährungsstudien verwendet werden können. Wir wendeten die Gleichung auf zwei große Datensätze an (National Diet and Nutrition Survey und National Health and Nutrition Examination Survey) und stellten fest, dass das Ausmaß der Falschangaben bei über 50 % lag. Die Makronährstoffzusammensetzung aus den Ernährungsberichten in diesen Studien war mit zunehmender Falschangabe systematisch verzerrt, was zu potenziell falschen Assoziationen zwischen Ernährungskomponenten und Body-Mass-Index führte.

Übersetzt mit www.DeepL.com/Translator (kostenlose Version)



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21.01.2025 um 18:13
Alles über Pflanzenöle / PUFAS / mehrfach ungesättigte Fettsäuren
Warum sind pflanzliche Öle gesundheitlich bedenklich bzw. wahrscheinlich gefährlich?

Dieses ausführliche Video fasst das Thema sehr gut zusammen. Ich füge eine Zusammenfassung von NoteGPT und ein komplettes Transkript bei.

Youtube: The $100 Billion Dollar Ingredient making your Food Toxic
The $100 Billion Dollar Ingredient making your Food Toxic
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Hier ist eine Missverständnis drin: Osman ist nicht der Autor des Videos :palm: Aber den Rest kann man im Großen und Ganzen unredigiert stehenlassen.
### Summary
In this thought-provoking video, mechanical engineer William Osman explores the controversial topic of vegetable oils and their impact on human health. Initially inspired by his experiment to incorporate sawdust into Rice Krispy Treats, Osman draws parallels between this seemingly innocuous culinary experiment and the widespread consumption of vegetable oils, which have replaced traditional animal fats in many diets over the past century. The video details the historical rise of vegetable oils from byproducts of crop processing to ubiquitous ingredients in modern cooking. Osman highlights concerning correlations between the increased intake of these oils and the rise in obesity, diabetes, and heart disease. Through a historical lens, the video examines the industrial processes behind vegetable oil production, the detrimental effects of polyunsaturated fats in the human body, and the findings of significant clinical studies that challenge the prevailing notion that vegetable oils are healthier alternatives to animal fats. Ultimately, Osman raises questions about the pervasive presence of vegetable oils in our diets and how they may be contributing to a hidden health crisis.

### Highlights
- 🥦 Osman tests sawdust as a food ingredient, revealing that it can replace 15% of Rice Krispy Treats without detection.
- 🏭 Vegetable oils' rise corresponds with increased rates of obesity and heart disease over the last century.
- 📜 The American Heart Association's recommendations in the 1960s promoted vegetable oils, despite a lack of correlation with heart disease rates.
- 🧪 The Minnesota Coronary Survey found no longevity benefit from vegetable oils, contradicting popular beliefs about their healthiness.
- 💔 Research indicates that polyunsaturated fats, particularly omega-6 linoleic acid, can damage mitochondria and contribute to various diseases.
- 🥗 A significant portion of modern diets consists of processed vegetable oils, which undergo extensive industrial processing that damages their structure.
- 🔍 Osman questions why the harmful effects of vegetable oils aren’t as widely discussed as sugar, considering their stealthy presence in many foods.

### Key Insights
- 🌳 **Sawdust in Food**: William Osman's initial experiment with sawdust as a food ingredient challenges perceptions of what can be consumed. This experiment serves as a metaphor for the greater issue of vegetable oils being an unnoticed yet significant part of the modern diet. The fact that sawdust could deceptively replace a portion of a beloved snack highlights how easily consumers may overlook the ingredients in their food, paralleling the unnoticed prevalence of vegetable oils.

- 📈 **Historical Context of Vegetable Oils**: The rise of vegetable oils in the American diet began in the late 19th century, driven by industrial advances and marketing campaigns that promoted their use as healthier alternatives to animal fats. This historical context is crucial in understanding how dietary shifts have contributed to modern health issues. The transition from traditional fats to vegetable oils represents one of the most significant changes in nutrition, affecting public health on a massive scale.

- ⚖️ **Correlation vs. Causation**: Osman emphasizes the correlation between increasing vegetable oil consumption and rising rates of obesity and diabetes. While correlation does not imply causation, the video suggests that the high levels of polyunsaturated fats in these oils could be contributing factors to these health crises. Understanding this relationship requires deeper investigation into dietary habits and their long-term effects on health.

- 📊 **The Minnesota Coronary Survey**: This landmark study revealed that while participants consuming vegetable oils had lower cholesterol levels, they did not experience longer lifespans. This finding contradicts the prevailing belief that reducing saturated fat intake leads to better health outcomes, suggesting that the health benefits of vegetable oils may be overstated. The delayed publication of the study results raises questions about the integrity of dietary research and the motivations underlying public health recommendations.

- 🧬 **Mitochondrial Dysfunction**: The video discusses how the consumption of vegetable oils may lead to mitochondrial dysfunction. Mitochondria are essential for energy production in cells, and their impairment can result in fatigue, reduced energy levels, and various diseases. This insight connects dietary choices with cellular health, underscoring the importance of fats in our diet and how certain types can be detrimental.

- 🔄 **Oxidation and Health Risks**: Osman explains the processes through which vegetable oils oxidize, creating harmful byproducts that can be toxic to the body. The ease of oxidation of polyunsaturated fats poses serious health risks, including the production of dangerous aldehydes that have been linked to various diseases. The video underscores the need for consumers to be aware of how the processing and storage of oils can affect their health.

- 🚫 **Lack of Awareness**: The video concludes by questioning why the dangers of vegetable oils aren't as widely recognized as those of sugar. This lack of awareness may stem from the subtle presence of vegetable oils in many processed foods, making them less noticeable compared to sugar, which has a more immediate and detectable impact on taste and health. Osman encourages viewers to consider the hidden ingredients in their diets and to educate themselves about the potential health implications of consuming vegetable oils.

In summary, this video not only presents the alarming implications of vegetable oil consumption on health but also encourages viewers to reflect on their dietary choices and the hidden ingredients in their food. Through a blend of historical context, scientific research, and personal anecdotes, Osman urges a reconsideration of what constitutes healthy eating in a world increasingly dominated by processed ingredients.



Das Transkript kommt aber in den Spoiler :)
=== === ===
Hier klicken:
TRANSCRIPT

Spoiler 00:02
In 2019, mechanical Engineer William Osman was  trying to figure out how to make use of a common waste product - sawdust. A walk in the park left  him thinking: People eat plants all the time, so why not eat trees? Osman decided to use sawdust  as a cheap alternative for a food ingredient. Considering the American food most resembling an  actual piece of wood is the Rice Krispy Treat, Osman decided to test how much of the  crisped rice he could replace with sawdust without consumers noticing. Incredibly, he found  you could replace 15% of the rice with sawdust


00:39
without too noticeable of a  difference in the final treat. "No idea. No way. I have literally no idea  there's sawdust in here. That's amazing." Osman’s switcheroo was very clever, but pales in  comparison to the gigantic switcheroo pulled on our global food supply over the past 100  years that would lead to today’s people switching out a very common type of food  that we had eaten for thousands of years… in favor of something edible but foreign  to the human diet and as I’ll argue here, maybe even toxic - vegetable oil. "Mazola corn  oil, Crisco oil, vegetable corn and sunflower


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oil." Low cost Vegetable oil is in everything  from packaged foods to restaurants and kitchens across the world. "Vegetable oil. Canola oil.  Vegetable Oil. Canola oil." As consumption of vegetable oils exploded, rates of obesity  and diabetes happened to explode with it. To understand why some doctors and scientists  are saying vegetable oils make us fat and diseased we need to look at some  history, some tapes hidden in a basement, how vegetable oils are actually made and what  actually happens in your body when you eat them.


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Let’s start in 1829 - thanks  to new machinery, it became practical to make use of the leftover garbage  from cotton production - cottonseeds. The oil extracted from cottonseed could be used as  fuel for lamps or lubricant for machinery. In the early 1880’s, Thomas Hudnut invented a  mechanical way to extract oil from corn germ. Up until then, corn germ was a  byproduct that corn refiners threw away. In 1898, Corn Oil started to be  used as commercial cooking oil. and in 1902, the Hudnut mills were selling  36 million gallons of corn oil per year.


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In 1911, the soap maker Procter and Gamble  came out with a new product - “crystallized cottonseed oil.” Crisco, looked a lot  like like the common cooking fat, lard. You see, before 1900 or so,  everyone used virtually 100% animal fats to cook. But Procter  and Gamble figured their newer, cheaper product Crisco looked a lot like lard,  so why not get people to eat Crisco instead? They launched a massive marketing campaign  presenting their cottonseed oil product as the newer and cleaner cooking fat  that made cheap, better tasting foods.


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Proctor and Gamble spent about 5  million dollars worth of today’s money in 1911 to advertise crisco  and it became popular immediately. Just the next year in 1912, sales  of crisco amounted to 2,600,000 lbs. That same year, 1912, James B. Herrick  published a paper on what is thought to be the first heart attack accurately  described in a medical journal. You see, heart disease was actually a very rare  condition before the 1900’s or so. Crisco continued to ramp up their advertising, and  in 1916, Crisco sales had reached 60,000,000 lbs.


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"When the heart stops beating,  death is not in fact instantaneous." In 1924 heart disease was rising and  the American Heart Association, the AHA, was founded but remained quite small  and poorly funded for quite a while. In 1945, soybean oil reached  1.3 billion pounds produced, overtaking cottonseed oil as the  leading edible oil in the United States. In 1948, The American Heart Association finally  got its big break when Procter and Gamble, the makers of Crisco, designated  the AHA to receive the 1.7 million


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dollars from Procter and Gamble’s radio contest. "and as the American Heart Association's own  history book reads, it says ...and overnight, millions poured into our coffers." Heart disease was still on the rise and in In  1955, President Dwight Eisenhower had a heart attack and the public was painfully aware  of just how big of a deal heart disease was. Then just 6 years later in 1961, the American  Heart Association had the answer to heart disease. The AHA recommended everyone to replace  saturated fats like those found in animal fat


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with polyunsaturated fats like those found in  vegetable oils to prevent heart attack and stroke. "It's 94% unsaturated, no oil is lower!2 By the way, saturated fat consumption  didn’t really correlate with rates of heart disease before or after 1961  when the AHA made their recommendation. And remember, we ate close to  zero grams of polyunsaturated fat rich vegetable oils before  1900 when heart disease was rare. "Okay so we went from zero in 1865 to 80 grams  a day. Now let me just say, this is an infinite


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increase in vegetable oil consumption. That makes  this the single greatest change to nutrition in all of history. I don't think  anything else can begin to compare. A third of our diet is coming out  of factories that make these oils!" Just like all these odd Corn Oil ads wanted us  to do, we added huge amounts of polyunsaturated fat to our diet and today edible oil is now  a $100 billion dollar industry. So is this massive increase in polyunsaturated fat rich  vegetable oil actually bad or just benign?


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You can find various anecdotes here and there of  people clearing up ailments as bad as arthritis or irritable bowel syndrome and losing plenty of  weight by removing vegetable oils from their diet. Molecular Biologist Brad Marshall even came up  with a croissant diet where he'd totally removed vegetable oils from his diet and lost plenty of  stubborn weight while eating croissants. Even Dr. Cate Shanahan, Nutritionist for the LA Lakers  removed vegetable oils from their diet plan. But these are just anecdotes so let’s move on.


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As mentioned vegetable oil consumption happens  to correlate with diabetes and obesity… but again we can’t get too excited,  this is just a correlation. Next, It’s well known that the  size of an animal relates to how long it will live - the larger an  animal, the longer it lives. But there are plenty of outliers - for example  humans can live over a 100 years but based on the size of humans, we should expect  a 70 kilogram human to live only 26 years. Also the 35 gram naked mole rat lives about 5 times  longer than we should expect from its size... Then… researchers found another way to  predict lifespan that accounts for some


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of these outliers like humans and the naked  mole rat. They found that if the cells of the animals are more made up of fats that are hard  to “oxidize” or break down, they live longer. If the fats in theirs cells are easy  to oxidize, they don’t live as long. And these vegetable oils we’re eating are  mainly comprised of polyunsaturated fat which is very easy to oxidize. Unfortunately for us, A 2015 review  in the American Society for Nutrition found that that the key polyunsaturated fat in  vegetable oils, an omega-6 fat called linoleic


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acid, accumulates and sits in our bodies the more  we eat it. The percentage of this linoleic acid in people’s fat cells has nearly doubled from  a bit under 10% in 1960 to around 20% in 2005 But remember, we were already eating  plenty of vegetable oil by 1955. "The next thing I'm going to show you I  searched for for 3 years. You know what I wanted to know? What was the omega-6 fat in  anybody's adipose who was on an ancestral diet." So what’s a normal linoleic acid  concentration? As Dr. Chris Knobbe discovered,


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these Pacific Islanders who were eating a diet  unadulterated by vegetable oils the amount of polyunsaturated linoleic acid was only 3.8%,  5 times less than what people are getting today. "3.8% people. This is where we should  be. And this is what keeps you healthy." So animals that have cells that oxidize easily  don’t live too long and we’ve been eating tons of these easily oxidizing oils. But what data do  we have on humans, vegetable oils and lifespan? "Dr. Frantz, I've heard the possibility that


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there might be some very interesting  data in your father's basement." This is cardiologist Robert Frantz on an episode  of Malcolm Gladwell’s revisionist history titled “The Basement Tapes,” concerning  Robert Frantz’s father, Ivan Frantz. “Ivan Frantz … chose… to devote  his life to studying heart disease; specifically, to understanding the role of  cholesterol and blood lipids in heart attacks…” Back in the 1960’s, Ivan Frantz conducted  a meticulously controlled study that would shed light on what actually happens  when people cut out saturated fats


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and eat polyunsaturated vegetable fats instead. The study which would be called “The Minnesota  Coronary Survey” took years to set up and had more than 9000 research subjects. Since  people were living in institutions, they could control exactly what the people  ate. It ran for five years from 1968 to 1973. “The patients in Frantz’s study would  go for their meals in the cafeteria and get one of two trays - they looked  completely identical, but one tray was food cooked with vegetable oil and everything low fat,  the other had everything cooked in saturated fat.”


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“This was a beautifully organized study.  There was lots of money and nothing; no holds were barred to try to do a good job.” “To this day, it stands as one of the  most rigorous diet trials ever conducted.” “So what does the Minnesota study show?  The patients on the vegetable oil died did end up with lower cholesterol than the  people who ate food cooked with animal fats, But the vegetable oil people didn't  live longer, which made no sense. They were eating the kind of died everyone  believed should help you live longer.”


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For whatever reason, Ivan Frantz  sat on his data for 15 years until he finally published the results in 1989.. "And his study was all but  forgotten for a quarter century." That is until Researcher at  the NIH, Christopher Ramdsen tracked down Ivan Frantz son for the old tapes  containing the raw data from this study … "The people who were over 65 who had been  on the diet for more than a year... The more their cholesterol was lowered, the  higher the risk of an adverse outcome." Here by "adverse outcome," he means death.


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"People over 65 were dying faster if  they ate a so called healthy diet." "There's no good evidence that reducing  saturated fat makes you live longer. The best clinical trials reached  the opposite conclusion." In Ramsden’s paper on the  Minnesota Coronary Survey, he essentially says that the reason we assumed  vegetable oils are healthy up until now is because researchers weren’t completely  publishing the actual results of their studies. Let me remind you that vegetable oils are  everywhere - in many packaged foods, chips,


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rice chips, crackers, salad dressings,  sauces, biscuits, mixed nuts, granola bars … most mayonnaises are basically a jar of  soybean oil. I’m not in the U.S. at the moment, but even most of these nicely packaged meals at  this expensive Japanese supermarket contain these cheap vegetable oils. Most restaurants and chefs  use vegetable oils because they have a neutral flavor,and well, they’re really cheap. People  have asked me what I think about plant-based meats and one reason I’m not keen on them is because  they’re simulating the fattiness of real meat


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with a bunch of vegetable oils. Canola, Soybean,  Grapeseed, Sunflower, Safflower, Corn and all kinds of polyunsaturated vegetable oils have  replaced saturated fats in our food supply. OK so Why? Why specifically would  vegetable oils be bad for our health? Well, Average Americans today are eating 5 to  6 tablespoons of vegetable oils per day. That’s around 700 calories of oil  filled with polyunsaturated fat. It’s almost impossible to  get this amount naturally. There’s so little oil per  ear of corn that it takes 98


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ears or 12,000 calories of corn to get you  5 tablespoons of corn oil. 625 grapes or 2,800 sunflower seeds will get you 5  tablespoons of grapeseed or sunflower oil. So a long industrial process is dedicated  to ripping oil out of tiny seeds. As mentioned earlier, polyunsaturated vegetable  fats oxidize very easily. “Oxidize” simply means to react with oxygen - this is how metals  rust and this is why meat that you leave out turns brown after a while. Oxidation changes the  structure and properties of fats for the worse.


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McDonald’s actually used to fry their fries in  Beef Fat, which was a really good idea because it tasted better and the saturated fat in  beef fat is very resistant to oxidation. It’s been common knowledge for a very long time  that it’s the unsaturated fats that are fragile and polyunsaturated fats are far more  fragile than monounsaturated fats. The main polyunsaturated fat in in vegetable oil  linoleic acid, is 40 times more prone to oxidation than the monounsaturated oleic  acid you find in olive oil.


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This is why your expensive bottle  of olive oil is dark green and says to store it in a cool, dark place. Olive oil is mostly monounsaturated fat, but 10% of it is fragile polyunsaturated fat Since light, exposure to oxygen and  especially heat all speed up oxidation, the olive oil will oxidize faster and worsen  the flavor if you don’t store it properly. That’s because when fats oxidize, they produce  oxidation products that give the fat a bad flavor, and these oxidation products are also toxic.


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For example, the toxic Aldehydes are one  of the fat oxidation products. In fact, acetaldehyde is thought to be what makes  you feel terrible during a hangover. Professor of Bioanalytical Chemistry  in the UK, Martin Grootveld, received some press for suggesting that  vegetable oils are not a healthy cooking oil despite the National Health Service saying  so. His research showed that meals fried in vegetable oil contain 100 to 200 times more  aldehydes than the daily limit set by the WHO. If you must to fry foods at high  temperatures, the far more resilient


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saturated fats like coconut oil or butter  produce far less of these harmful compounds. Ironically, the reason McDonald’s switched to  frying everything in vegetable oil was thanks to Phil Sokolof, a Nebraskan millionaire who  in 1985 began spending his personal fortune on his crusade to stop others  from consuming saturated fats which Sokolof thought were responsible for his  heart attack. His extensive anti-saturated fat marketing campaign was effective and  eventually McDonald’s backed down and


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swapped oxidation resistant Beef Tallow for  easily oxidizable Vegetable Oil in 1990. The intense processing necessary to  simply get the oil out of tiny seeds and into bottles easily damages them. Heat is a great way to oxidize fats, and vegetable  oil is repeatedly heated long before it ever arrives in a kitchen. There are many steps to  create edible oil and some involve very high heat. The oil is heated to 80°C (176°F)  during the acid wash process in the neutralization process, the  oil can get up to 95°C (200°F),


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the bleaching process is carried out  between 90 and 110 degrees°C (230°F) At this point the oil has oxidized so  much that it’s rancid and would taste and smell awful if you ate it as is. This is why  there is a final intensive deodorization process. During this extensive deodorization process, the  oil is heated once again and can reach as high as 260°C or 500°F. That’s 125 degrees hotter  than the temperature needed for deep frying. There’s something called the Israeli  paradox. Israel has one of the highest


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omega-6 polyunsaturated fat consumptions  in the world; their omega-6 consumption is 8% higher than the USA and 10-12% higher  than most of Europe. To quote this paper,: “Despite such national habits, there  is a paradoxically high prevalence of cardiovascular diseases, hypertension,  [type 2 diabetes], and obesity.” Now the other thing about the fragile  polyunsaturated omega-6 linoleic acids in vegetable oils, is they’re still problematic  even if not heated. Heat isn’t the only way to oxidize vegetable oils. They can just oxidize  sitting on the shelf - walnut oil for example


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which has plenty of linoleic acid, will  readily oxidize in just a matter of days while simply sitting in  storage as you can see here. Vegetable oils also oxidize while sitting in  your body, creating toxic oxidation products like an aldehyde called 4-HNE. 4-HNE is in  fact considered to be the most toxic aldehyde and this compound has been associated with  aging, heart disease, diabetes and alzheimer’s Neuroscientist Testumori Yamashima has done  plenty of research on vegetable oils and 4-HNE.


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He’s published multiple papers on  the damaging effects of this compound and why people need to avoid vegetable oils cause  they oxidize into 4-HNE in our bodies. This book of his is titled “Stop eating vegetable oils to  save your brain and blood vessels.” He’s even gone as far as to say that the real culprit  behind Alzheimer’s disease is vegetable oil. Now that's just the research of one  neuroscientist, but other research at Lewis Katz School of Medicine at Temple  University found Canola oil in the diet to


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be associated with worsened memory, worsened  learning ability and weight gain in mice. Also, Alzheimer’s prevalence as happens to  correlate with vegetable oil consumption, but again, this is just a correlation. Do you ever feel more tired than  you should be? Like you’re just low on “energy” and can’t concentrate for  seemingly no reason and you’re thinking “Is it normal to require this much  coffee to muster the energy to function?” But what is “energy” when talking about the body? Here’s a Pop quiz: What do breathing, food,  cyanide and Star Wars all have in common?


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Midichlorians. The microscopic  life forms living in the cells of living things that determine  your propensity to use the force. Actually No, but midichlorians are  obviously based off of mitochondria. Mitochondria are found in nearly  all cells in the human body, they are the powerhouse of the cell and the  reason you breathe and eat food. Mitochondria use food calories and oxygen to create  energy in the form of a compound called ATP. We are incredibly reliant on our mitochondria to  smoothly and efficiently produce massive amounts


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of ATP energy. We need so much energy that if you  took all the molecules of ATP you made in a day and put it on the scale, it would weigh as much  as you. We make our body weight in ATP every day. If you messed up this energy supply, things  would go haywire rapidly . This is how cyanide kills people so quickly - it damages the  mitochondria’s ability to make energy. Unsurprisingly, some instances of  feelings of excessively low energy or fatigue have been linked to  poor mitochondria function.


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Evolutionary Biologist, Dr. Douglas C.  Wallace is arguing here that medicine focuses too much on anatomy and  not enough on animation - that is, the energy production necessary  to animate the anatomy. Scientists are starting to see that mitochondrial  dysfunction may play a central role in the development of many diseases, including heart  disease and Alzheimer’s. That’s not all that surprising because the heart and brain require  massive amounts of energy to work properly. It’s also well known that mitochondria  are dysfunctional in obesity and diabetes.


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In fact, the world’s most prescribed  diabetes drug - metformin, which is one of the few that also helps patients  lose weight, acts on the mitochondria. So where does vegetable oil come into play? Well, surprise surprise, vegetable  oils can damage the mitochondria. To make this real simple, you can think of the  mitochondria as a conveyor belt at a factory that’s pumping out ATP energy. After your  body pulls electrons from the food you ate complexes and electron transporters  pass electrons down this conveyor belt,


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the inner membrane of the mitochondria. This  results in protons being pumped up here and then the protons get sucked into this  ATP synthesis enzyme to make ATP. Now, the conveyor belt, the inner membrane,  has plenty of something called cardiolipin. This is important because this is what’s damaged  when you consume plenty of vegetable oils. When the linoleic acid from vegetable oils  accumulate in your body, you can get what’s called a peroxidation cascade where kind of like  dominoes, one molecule of linoleic acid oxidizes


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and produces a substance that can oxidize another  molecule of linoleic acid and this produces more of that substance that can damage another molecule  of linoleic acid and so on and so on. It’s a chain reaction. This chain reaction can go on to  affect the cardiolipin in your mitochondria. As this study shows here, when rats eat  a linoleic acid rich vegetable oil diet, markers of oxidized fat doubled … and in  the heart, the content of cardiolipin, the stuff your mitochondria needs to  properly produce energy, was reduced 5-fold.


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In this study, the cardiolipin of diabetic  and non-diabetic rats reduced drastically when they were fed a vegetable oil diet,  and the mitochondria of the vegetable oil fed diabetic rats completely  collapsed into these crumpled blobs. Even the textbook Recent Advances  in Mitochondrial Medicine acknowledges that omega-6 fatty acids like those  found in vegetable oil may damage various organs, including the pancreas which would worsen  metabolic syndrome and type 2 diabetes. So.. going back to the first study, what happened  to the normal rats whose mitochondrial cardiolipin


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was reduced so much from eating vegetable oils?  In just four weeks, these rats had heart failure. Developing heart failure that fast is very  alarming, but of course humans are not rats so it’s not like eating a bunch of mayonnaise  will give you heart failure in a couple weeks, it’s going to take a very long time  of consuming plenty of vegetable oil for damage to become apparent. But, how long? Well, let me mention one last study, the 1969  LA Veterans Administration Hospital study, another very well controlled clinical diet trial


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where people over 60 were given  either animal fats or vegetable oils. To cut to the chase, the people in the  vegetable oil group were dying more… and this was the case even though there were twice  as many heavy smokers in the animal fat group. The interesting part is that this study  was so long - 8 years. And it took many years to clearly see the negative  effect of the vegetable oil diet. The study authors concluded that to truly  understand the negative health effect of vegetable oils, maybe studies need to be much longer than  8 years, but most only lasted 5 years at best.


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So to sum all this up: Vegetable oils rich  in the polyunsaturated omega-6 fat linoleic acid displaced saturated fats which we had been  eating for thousands of years. The consumption of these new oils happen to correlate with  rates of obesity, diabetes and Alzheimer’s. Correlations are just correlations, but  it is well known that polyunsaturated fats oxidize very easily, creating oxidation products  which are toxic to humans. Not only that, but linoleic acid accumulates in  the body where it can oxidize,


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creating these harmful oxidation products  and damaging our mitochondria. And lastly, well controlled clinical trials have found worse  outcomes for people on a vegetable oil diet. So Something I’ve been thinking about  is - if this is such a big deal, why isn’t this a bigger topic? Why aren’t more  people interested in vegetable oils the way people are interested in health effects of say  sugar? Well, I think the difference is sugar tastes and makes us feel great. If you took it out  of your food, you’d definitely notice. So I think


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some people intuitively think “this has got to be  too good to be true… maybe sugar is bad for me.” But with vegetable oils, they’re a lot  like the sawdust in William Osman’s rice krispy treats - they’re just there,  hard to notice, hiding in your food. I mean, how often do you think about the fat  used to make your food? If someone swapped the sugar in your coffee for stevia or Splenda,  you’d notice pretty quickly, but could you even tell if the aromatic vegetables you ordered  were sautéed in canola oil instead of butter?






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